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Abstract
Circular RNAs (circRNAs) may enable long-lasting protein expression due to their resistance to degradation.
- CircRNAs are formed through a process called back-splicing, resulting in a covalently closed circular structure.
- These RNA molecules are less susceptible to degradation by enzymes and show reduced immune system activation.
- Endogenous circRNAs can affect gene expression by interacting with other molecules and may enhance protein production without the need for a cap structure.
- Dysregulated circRNAs have been linked to various diseases, including cancer and metabolic disorders.
- Recent advancements in technology allow for the efficient creation of synthetic circRNAs with improved properties for therapeutic use.
- Innovations in delivery methods such as lipid nanoparticles and viral vectors are expanding the potential applications of circRNAs in treating diseases.
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