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Entrapment of Conjunctival Goblet Cells by Desiccation-Induced Cornification
Drying causes surface eye cells that produce mucus to become trapped by skin-like changes
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Abstract
Levels of involucrin and several cornified envelope precursor proteins increased in ocular surface tissues in response to desiccating stress.
- Desiccating stress led to an increase in mRNA transcripts for involucrin and various cornified envelope precursor proteins.
- The expression and activity of the enzyme transglutaminase 1 in the conjunctiva significantly increased after exposure to desiccating stress.
- Desiccating stress caused a progressive loss of mucin-filled goblet cells in the conjunctiva.
- Remaining goblet cells became trapped by adjacent epithelial cells, which increased their levels of cornified envelope precursors.
- This process may be linked to the conjunctival mucin deficiency observed in dry eye conditions.
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