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Esketamine's impact on confusion after surgery with general anesthesia: a combined analysis of clinical trials
Updated
Abstract
Esketamine significantly reduced the incidence of in 1286 patients undergoing elective general anesthesia (RR: 0.43; 95% CI: 0.33 ~ 0.57; p < 0.001).
- The analysis included 17 randomized controlled trials focused on patients receiving general anesthesia.
- No significant difference in the incidence of postoperative adverse events such as nausea, vomiting, dizziness, and respiratory depression was observed between the esketamine group and the control group (RR: 0.82; 95% CI: 0.65 ~ 1.03; p = 0.08).
- The esketamine group exhibited a lower incidence of hypotension compared to controls (RR: 0.24; 95% CI: 0.12 ~ 0.48; p < 0.001).
- Patients in the esketamine group reported lower pain scores on the visual analogue scale 24 hours after surgery (MD: -0.44; 95% CI: -0.54 ~ -0.33; p < 0.001).
Simplified
Key numbers
0.43
Reduction in Incidence
Risk ratio comparing esketamine vs. control group for incidence
0.24
Incidence of Hypotension
Risk ratio for hypotension incidence in esketamine vs. control group
-0.44
VAS Score Reduction
Mean difference in VAS scores 24 hours after surgery between esketamine and control groups