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Effect of remimazolam on postoperative delirium and cognitive function in adults undergoing general anesthesia or procedural sedation: a meta-analysis of randomized controlled trials
Remimazolam's impact on confusion and thinking after surgery or sedation in adults: a combined analysis of clinical trials
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Abstract
In a study of 1295 patients, remimazolam was associated with an 8.0% incidence of postoperative delirium compared to 10.4% with propofol.
- The difference in postoperative delirium rates between remimazolam and propofol was not statistically significant (odds ratio: 0.74).
- Patients receiving remimazolam showed more favorable cognitive function, as indicated by a higher score on the Mini-Mental State Examination.
- The mean difference in cognitive function scores favoring remimazolam was 1.06, with statistical significance (P = 0.005).
- Remimazolam resulted in a lower incidence of hypotension compared to propofol (odds ratio: 0.28).
- Remimazolam maintained better hemodynamic stability during surgery compared to propofol.
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Key numbers
8.0%
Postoperative Delirium Incidence
Incidence in the remimazolam group (44 cases out of 552).
1.06
Cognitive Function Improvement
Mean difference in Mini-Mental State Examination scores.
0.28
Hypotension Incidence Reduction
Odds ratio comparing remimazolam to propofol.