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Essential oil from Lippia microphylla Cham. modulates nitric oxide pathway and calcium influx to exert a tocolytic effect in rat uterus
Lippia microphylla essential oil may relax rat uterus by affecting nitric oxide and calcium pathways
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Abstract
LM-OE inhibited phasic contractions and relaxed tonic contractions in the rat uterus.
- The essential oil of Lippia microphylla (LM-OE) demonstrates tocolytic effects in rats.
- Inhibition of nitric oxide synthase reduced the potency of LM-OE, indicating a role for nitric oxide in uterine contraction regulation.
- The relaxant effects of LM-OE were diminished when soluble guanylyl cyclase and protein kinase G inhibitors were present.
- LM-OE positively modulates various potassium channels and inhibits calcium influx, suggesting blockade of voltage-gated calcium channels type-1.
- The findings indicate that the tocolytic effect of LM-OE may involve the modulation of the NO/NOS/sGC/PKG/K-channels pathway.
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