Evening chronotype associates with obesity in severely obese subjects: interaction with CLOCK 3111T/C

Evening-type individuals exhibited higher initial body weight and lost less weight after bariatric surgery compared to morning types.

• Evening-type subjects had significantly higher initial body weight and BMI than morning types.
• Those with an evening chronotype lost a lower percentage of excess weight after bariatric surgery.
• Weight-loss progression indicated greater weight regain among evening types starting from the fourth year post-surgery.
• A significant interaction was found between the CLOCK 3111T/C genetic variant and chronotype concerning body weight at baseline.
• Among carriers of the risk allele C, evening types had higher body weight than morning types.
• The CLOCK 3111T/C variant was significantly associated with obesity and sleep duration in older individuals.

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