Exenatide changes the liver's daily clock over time through brain receptors for glucagon-like peptide-1

Exenatide administration at ZT 12 counteracted the phase shift effect of the L-TRF on the hepatic clock in wild-type mice.

• Circadian clock disruption may contribute to lifestyle-related diseases.
• Exenatide affects the molecular clocks in peripheral tissues.
• Dosing time of exenatide influences the hepatic clock in mice.
• Administration at the beginning of the dark period (ZT 12) mitigated the effects of light-based feeding restrictions.
• Dosing at the beginning of the light period (ZT 0) enhanced the effect on the hepatic clock.
• No influence on the phase of the hepatic clock was observed under dark feeding restrictions, regardless of dosing time.

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