Biochimica et biophysica acta. Molecular and cell biology of lipids

How exercise affects two types of fat cells that burn energy

Updated

Abstract

Exercise may lead to a down-regulation of brown adipose tissue activity in humans, as indicated by reduced glucose uptake.

  • Physical exercise is associated with beneficial effects on various tissues and organ systems.
  • Significant adaptations occur in brown adipose tissue (BAT) and white adipose tissue (WAT) due to exercise.
  • Conflicting results have been reported regarding the thermogenic activity of BAT, with some studies showing increased activity and others showing decreased activity.
  • In white adipose tissue, exercise is linked to decreased fat cell size, changes in gene expression, and enhanced mitochondrial function.
  • Transplanting exercise-trained subcutaneous white adipose tissue (scWAT) may improve overall metabolic health.
  • In rodents, exercise induces a process known as beiging in subcutaneous white adipose tissue.

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