The effect of exercise training on glucose tolerance and skeletal muscle triacylglycerol content in rats fed with a high-fat diet.

Exercise training improved glucose tolerance and insulin response in control rats fed a standard diet, but had limited effects on those fed a high-fat diet.

• Male Wistar rats on a high-fat diet developed significant hyperinsulinemia.
• Exercise training enhanced glucose tolerance and insulin response only in control rats, with a notable difference in glucose and insulin area under the curve.
• Liver glycogen levels were significantly lower in high-fat diet rats compared to control rats and did not increase with exercise training.
• Triglyceride content in muscle and liver was significantly higher in high-fat diet rats compared to controls.
• Exercise training increased triglyceride content in control rats across most tissues, except for the white gastrocnemius.
• Despite exercise training, triglyceride levels remained markedly higher in high-fat diet rats compared to controls.

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