High-fat diet impairs the effects of a single bout of endurance exercise on glucose transport and insulin sensitivity in rat skeletal muscle

Insulin-independent glucose transport in skeletal muscle was 25% lower in high-fat diet-fed rats compared to control diet-fed rats after exercise.

• A single session of exercise increases glucose transport in muscles through both insulin-independent and insulin-dependent pathways.
• High-fat diet feeding for 4 weeks decreased insulin-independent glucose transport after exercise compared to a control diet.
• Exercise also improved insulin-dependent glucose transport in both dietary groups, but this was similarly reduced by 25% in high-fat diet-fed rats.
• Activation of a key signaling protein involved in glucose transport and insulin sensitivity was diminished in rats on a high-fat diet during exercise.
• High-fat diet did not alter the content of a specific glucose transporter or the phosphorylation of a protein activated by insulin.

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