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A High-fructose Diet Impairs Akt and PKCζ Phosphorylation and GLUT4 Translocation in Rat Skeletal Muscle
A high-fructose diet reduces key protein activation and sugar transport in rat muscle
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Abstract
Fructose-fed rats showed a significant decrease in the glucose infusion rate and metabolic clearance rate of glucose during insulin infusion.
- High-fructose feeding resulted in reduced insulin-stimulated glucose infusion rate and metabolic clearance rate compared to chow-fed rats.
- Protein levels of key signaling proteins (Akt, PKCzeta, GLUT4) remained unchanged in the skeletal muscle of fructose-fed rats.
- Impaired activation of Akt and PKCzeta was observed in response to insulin in fructose-fed rats.
- GLUT4 translocation to the plasma membrane was decreased in fructose-fed rats following insulin stimulation.
- Insulin resistance in fructose-fed rats is associated with these reductions in signaling and translocation processes.
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