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Exploring the Impact of the Gut Microbiota/REV-ERBα/NF-κB Axis on the Circadian Rhythmicity of Gout Flares from a Chronobiological Perspective
How Gut Bacteria and Inflammation Control Daily Patterns of Gout Attacks
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Abstract
The may influence the circadian rhythmicity of gout flares by modulating serum uric acid levels.
- The NF-κB signaling pathway is a central inflammatory process in gout and shows strong circadian patterns.
- Circadian clock genes, particularly REV-ERBα, regulate the NF-κB pathway in relation to gout inflammation.
- Circadian variations in serum uric acid levels may be induced by the gut microbiota's influence on REV-ERBα expression.
- The interaction of the gut microbiota, REV-ERBα, and NF-κB signaling could explain the timing of gout flare occurrences.
- Chronobiology-based therapies targeting this gut microbiota/REV-ERBα/NF-κB axis may offer new treatment strategies for gout.
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Key numbers
31 million
Increase in Gout Patients
Increase in global gout patients over nearly three decades.
3×
Circadian Likelihood of Gout Flares
Increased likelihood of nocturnal gout attacks.