Oxidative Stress and Inflammation Modulate Rev-erbα Signaling in the Neonatal Lung and Affect Circadian Rhythmicity

A unique sequence on the mouse Rev-erbα promoter mediates its response to oxidative stress and inflammation.

• The identified sequence consists of overlapping AP-1 and NFκB consensus sequences that regulate Rev-erbα activity.
• Oxidative stress can enhance Rev-erbα transcription by overcoming NFκB's inhibitory influence.
• In neonatal mice, hyperoxia increased lung Rev-erbα transcription, especially when NFκB was disrupted.
• Alterations in Rev-erbα rhythmicity were observed following pre-exposure to hyperoxia or NFκB disruption in cell culture.
• The observed effects on Rev-erbα transcription and oscillation are linked to its role in lung cellular function and injury.

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