Familial components of the multiple metabolic syndrome: the ARIC Study

Aug 1, 1997Diabetologia

Family factors linked to multiple metabolic syndrome: the ARIC study

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Abstract

MMS cases (n = 356) were more likely to report a parental history of diabetes than disorder-free controls (n = 6797), with an odds ratio of 4.7.

A history of hypertension in both parents was associated with an increased odds of MMS (odds ratio 1.9).
The highest increase in odds of MMS was observed with a parental history of both diabetes and hypertension (odds ratio 8.3).
A dose-response relationship was noted between the number of parental disorders and the odds of MMS.
Specifically, one disorder increased the odds by 1.2, two disorders by 2.0, and three to four disorders by 4.0.
These findings suggest that both genetic and non-genetic familial factors may influence the development of multiple metabolic syndrome.

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The association of a parental history of diabetes mellitus and hypertension with the multiple metabolic syndrome (MMS) was studied in a population survey of middle-aged adults. The eligible population was drawn from the baseline examination of the Atherosclerosis Risk in Communities Study, a population-based, bi-ethnic, multi-centre cohort study. The MMS was defined as a multivariate, categorical phenotype of co-occurring diabetes, hypertension, and dyslipidaemia. MMS cases (n = 356) were compared to disorder-free control subjects (n = 6797) with respect to their parental history of diabetes and hypertension. MMS cases were more likely to report a history of diabetes in both parents (odds ratio [OR] 4.7, 95 % confidence interval (CI) 1.5-14.7) or a history of hypertension in both parents (OR 1.9, 95 % CI 1.1-3.0) than control subjects, adjusting for BMI, waist-to-hip ratio, age, gender, and ethnicity/centre. A parental history of diabetes and hypertension in both parents was associated with the greatest increase in odds of MMS (OR 8.3, 95 % CI 3.0-22.8). A dose-response relationship between the number of parental disorders (one; two; three to four) and the odds of MMS was observed (OR 1.2, 95 % CI 0.9-1.7; OR 2.0, 95 % CI 1.4-2.8; OR 4.0, 95 % CI 2.5-6.2). Based on the marked associations observed between a parental history of MMS components and the clustering of these metabolic disorders in the offspring generation, we conclude that genetic and/or non-genetic familial influences play a role in the development of the multiple metabolic syndrome.

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Familial components of the multiple metabolic syndrome: the ARIC Study

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