Association between parental histories of hypertension, diabetes and dyslipidemia and the clustering of these disorders in offspring

Mar 3, 2006Preventive medicine

Parents' high blood pressure, diabetes, and cholesterol linked to these health problems occurring together in their children

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Abstract

Individuals with a maternal history of hypertension, diabetes, or dyslipidemia may have a 1.69 times higher risk of developing clusters of these disorders.

A total of 5010 Japanese men and women, aged 33-66 years, were assessed for associations between parental histories and disease clustering.
Having one, two, or three or more parental histories of the three diseases was linked to increased risk factor clusters.
Specifically, individuals with one, two, and three or more maternal histories had odds ratios of 1.33, 1.65, and 1.69 for risk factor clusters.
No association was found between the number of paternal histories and risk factor clusters.
Maternal history appears to be a significant factor in determining the risk of metabolic disorders.

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BACKGROUND: Familial aggregation of hypertension, diabetes and dyslipidemia has been well reported. However, only a few studies have assessed to what extent parental histories were involved in the clustering of these diseases.

METHOD: In 2002, associations between parental histories of hypertension, diabetes and dyslipidemia and the clustering of high blood pressure, hyperglycemia and dyslipidemia in individuals were assessed on the basis of 5010 Japanese men and women aged 33-66 years. Risk factor clusters were defined as those having at least two of the three clinical disorders.

RESULTS: Compared with persons with no parental history of the three diseases, those who had 1, 2 and 3 or more parental histories had risk factor clusters, 1.25 (95% CI: 1.07, 1.47), 1.46 (95% CI: 1.16, 1.84) and 1.41 (95% CI: 0.95, 2.11) times higher, respectively, after adjusting for confounding factors. ORs by 1, 2 and 3 of maternal history were 1.33 (95% CI: 1.12, 1.58), 1.65 (95% CI: 1.16, 2.35) and 1.69 (95% CI: 0.64, 4.42), respectively (trend P < 0.001). However, the number of paternal history was not associated with risk factor clusters.

CONCLUSION: We conclude that familial history, particularly maternal history, is an important aid to prevention strategy and public health practice for metabolic disorders.

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Association between parental histories of hypertension, diabetes and dyslipidemia and the clustering of these disorders in offspring

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