Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle

Fasting alters core clock genes and proteins, leading to disrupted rhythmicity in BMAL1 and REV-ERBα in both liver and skeletal muscle.

• The transcriptional response to fasting differs from that of time-restricted feeding.
• Fasting activates specific transcription factors, including GR, CREB, FOXO, TFEB, and PPARs, which influence gene expression timing.
• The genomic response to fasting can be sustained through prolonged fasting and reversed upon refeeding.
• Fasting appears to create a unique interaction between the circadian clock and nutrient-sensitive pathways.

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