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Fasting changes daily rhythms in kidney cells to control glucose reabsorption through the Nrf1/Sglt2 pathway in mice
Updated
Abstract
Essence
In mice, fasting uses proximal-tubule circadian machinery to reduce -dependent kidney glucose reabsorption.
Evidence
A mechanistic mouse study found that fasting-induced glucagon increases and Rev-erb alpha, repressing , lowering Sglt2 expression, and reducing renal glucose reabsorption capacity.
Caveat
The evidence is from mice and local kidney clock mechanisms, so it does not establish the same fasting-refeeding control in humans.
Simplified
Key numbers
5-fold
Increase in glucose uptake
Glucose uptake in after serum supplementation.
50%
Decrease in glucose uptake
Glucose uptake in after serum deprivation.
2 to 3-fold
2- to 3-fold increase in protein levels
Comparison of and protein levels in deficient vs. wild-type mice.
Circadian Biology