Fat utilization during exercise: adaptation to a fat-rich diet increases utilization of plasma fatty acids and very low density lipoprotein-triacylglycerol in humans

Leg fatty acid uptake was 183 ± 37 micromol min(-1) in subjects consuming a fat-rich diet.

• Subjects on a fat-rich diet had a significantly lower respiratory exchange ratio (0.86 ± 0.01) compared to those on a carbohydrate-rich diet (0.93 ± 0.02).
• Very low density lipoprotein-triacylglycerol uptake was higher in the fat-rich diet group (132 ± 26 micromol min(-1)) versus the carbohydrate group (16 ± 21 micromol min(-1)).
• Whole-body plasma fatty acid oxidation was higher after the fat-rich diet (13.5 ± 1.2 micromol min(-1) kg(-1)) compared to the carbohydrate diet (8.9 ± 1.1 micromol min(-1) kg(-1)).
• Muscle glycogen breakdown was lower in the fat-rich diet group (2.6 ± 0.5 mmol (kg dry weight)(-1) min(-1)) compared to the carbohydrate group (4.8 ± 0.5 mmol (kg dry weight)(-1) min(-1)).
• Leg glucose uptake was similar between both diet groups (1.07 ± 0.13 vs. 1.15 ± 0.13 mmol min(-1)).

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