Partial restoration of dietary fat induced metabolic adaptations to training by 7 days of carbohydrate diet

After 8 weeks, average leg glucose uptake was 1.00 +/- 0.07 mmol/min in the high-fat diet group, significantly lower than the 1.55 +/- 0.21 mmol/min in the high-carbohydrate group.

• A shift from a high-fat to a high-carbohydrate diet after prolonged adaptation resulted in lower glucose uptake during exercise.
• Despite higher preexercise muscle glycogen levels in the high-fat group, the rate of muscle glycogen breakdown was similar to that in the high-carbohydrate group.
• Muscle glycogen levels were increased in the high-fat diet group, but this did not translate into improved glucose uptake during exercise.

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