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The effects of Fc fusion protein glucagon-like peptide-1 and glucagon dual receptor agonist with different receptor selectivity in vivo studies
Effects of a dual hormone-activating fusion protein with different receptor preferences in live studies
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Abstract
The lowest observed adverse effect level (LOAEL) of HEC-C070 was 30 nmol/kg in toxicity studies.
- HEC-C046, with high glucagon receptor selectivity, showed significant weight loss and improvements in metabolic parameters but raised safety concerns.
- HEC-C052, which has the lowest glucagon receptor activity, resulted in less weight loss compared to the selective GLP-1 receptor agonist semaglutide in diet-induced obese mice.
- HEC-C070 demonstrated moderate glucagon activity and had a notable impact on weight loss and liver function in obese mice.
- The study evaluates the effects of different dual receptor agonists on weight and liver health in various obese mouse models.
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