Five years of research on 2,4-thiazolidinediones as anticancer agents: medicinal chemistry insights (2020–2024)

2,4-Thiazolidinedione derivatives have shown promise as anticancer agents by influencing key molecular pathways involved in tumor development.

• 2,4-TZDs traditionally recognized for antidiabetic properties are now being explored for their potential in cancer treatment.
• These compounds can affect processes such as cell growth, programmed cell death, blood vessel formation, and cancer spread.
• Structural modifications at the C-5 position of 2,4-TZDs allow for adjustments in their biological activity and targeting capabilities.
• Recent evaluations (2020-2024) highlight how different chemical changes impact the effectiveness and selectivity of these compounds against cancer cells.
• Insights into the molecular mechanisms of selected 2,4-TZD derivatives provide a deeper understanding of their anticancer effects.

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