Meta‐analysis Added Power to Identify Variants in FTO Associated With Type 2 Diabetes and Obesity in the Asian Population

Jan 9, 2010Obesity (Silver Spring, Md.)

Combined studies improve identification of FTO gene variants linked to type 2 diabetes and obesity in Asian people

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Abstract

The minor allele A of rs9939609 and rs8050136 in the FTO gene is associated with increased risk of type 2 diabetes and obesity in a study of 4,189 Chinese Han individuals.

Both variants were linked to a higher risk of type 2 diabetes, with odds ratios of 1.19 for rs9939609 and 1.22 for rs8050136.
The association with type 2 diabetes was independent of body mass index (BMI).
Increased risk of obesity was also observed, with odds ratios of 1.39 for rs9939609 and 1.45 for rs8050136.
No association was found between these variants and overweight status.
Findings were supported by a meta-analysis of published studies in Asian populations.

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Several common variants in the intron 1 of FTO (fat mass and associated obesity) gene have been reliably associated with BMI and obesity in European populations. We analyzed two variants (rs9939609 and rs8050136) in 4,189 Chinese Han individuals and conducted a meta-analysis of published studies in Asian population to investigate whether these variants are associated with type 2 diabetes (T2D) and obesity in Asian population. In this study, both the minor allele A of rs9939609 and the minor allele A of rs805136 were associated with increased risk of T2D, independent of measures of BMI; the odds ratios (ORs) per copy of the risk allele were 1.19 for rs9939609 (95% confidence interval (CI), 1.04-1.37; P = 0.01) and 1.22 for rs8050136 (95% CI, 1.07-1.40; P = 0.004) after adjusting for age, sex, and BMI. Our results also showed association with risk of obesity (rs9939609: OR = 1.39 (95% CI 1.04-1.85), P = 0.02; rs8050136: OR = 1.45 (95% CI 1.09-1.93), P = 0.01) but no association with overweight. These results were consistent with the pooled results from our meta-analysis study (for diabetes, rs8050136, P = 1.3 x 10(-3); rs9939609, P = 9.8 x 10(-4); for obesity, rs8050136, P = 2.2 x 10(-7); rs9939609, P = 9.0 x 10(-9)). Our findings indicate that the two variants (rs9939609 and rs8050136) in the FTO gene contribute to obesity and T2D in the Asian populations.

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Meta‐analysis Added Power to Identify Variants in FTO Associated With Type 2 Diabetes and Obesity in the Asian Population

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