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A functional subdivision of the circadian clock is revealed by differential effects of melatonin administration
Different parts of the body’s internal clock respond differently to melatonin
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Abstract
A single melatonin injection at the light/dark transition significantly increases endogenous pineal melatonin levels for the following two days.
- Melatonin injection affects specific components of the circadian clock.
- Pineal melatonin secretion shows a marked increase after melatonin administration.
- The amplitude of the corticosterone rhythm remains unchanged following melatonin treatment.
- These findings suggest melatonin influences a selective group of neurons related to the pineal pathway.
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