Full text is available at the source.
Melatonin in the multi‐oscillatory mammalian circadian world
Melatonin's role in the multiple internal clocks of mammals
AI simplified
Abstract
Melatonin may stabilize and reinforce circadian rhythms by acting on the circadian clock.
- The suprachiasmatic nucleus (SCN) orchestrates circadian rhythms through a network of neural, hormonal, and behavioral signals.
- Melatonin serves as an endogenous synchronizer, providing circadian information to maintain the phase relationship of various oscillators.
- Exogenous melatonin can influence all levels of the circadian network, potentially impacting overall circadian function.
- In rats, REV-ERB alpha appears to be the initial molecular target for the chronobiotic effects of melatonin.
AI simplified