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Changes in digestion movement and gut hormone levels after two types of weight-loss surgery in people with severe obesity
Updated
Abstract
After both Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), significantly accelerated.
- Postprandial release of the GLP-1 and PYY significantly increased after both surgeries, indicating activation of the ileal brake.
- significantly accelerated after SG but not after RYGB.
- No significant correlations were found between changes in gut peptide release, GI motility, and clinical parameters.
- Both SG and RYGB resulted in significant weight loss and affected GI motility and gut peptide secretion.
- Subtle differences were observed in the effects on oro-cecal transit time and patterns of peptide secretion between the two procedures.
Simplified
Key numbers
263 min to 128 min
T1/2 Decrease
half-time after at baseline and 2 months post-surgery.
150 min to 60 min
Reduction
after from baseline to 12 months post-surgery.
2 months post-
Increase
Significant increase in of secretion compared to preoperative levels.