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Changes in gastrointestinal motility and gut hormone secretion after Roux‐en‐Y gastric bypass and sleeve gastrectomy for individuals with severe obesity
Changes in digestion movement and gut hormone levels after two types of weight-loss surgery in people with severe obesity
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Abstract
After both Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), significantly accelerated.
- Postprandial release of the GLP-1 and PYY significantly increased after both surgeries, indicating activation of the ileal brake.
- significantly accelerated after SG but not after RYGB.
- No significant correlations were found between changes in gut peptide release, GI motility, and clinical parameters.
- Both SG and RYGB resulted in significant weight loss and affected GI motility and gut peptide secretion.
- Subtle differences were observed in the effects on oro-cecal transit time and patterns of peptide secretion between the two procedures.
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Key numbers
263 min to 128 min
T1/2 Decrease
half-time after at baseline and 2 months post-surgery.
150 min to 60 min
Reduction
after from baseline to 12 months post-surgery.
2 months post-
Increase
Significant increase in of secretion compared to preoperative levels.