Full text is available at the source.
Generation of myometrium-specific Bmal1 knockout mice for parturition analysis
Creating mice without the Bmal1 gene in the uterine muscle to study childbirth
AI simplified
Abstract
Ninety-two percent of control females completed parturition during the expected time window, compared to only 64% of females with disrupted myometrial Bmal1.
- Circadian rhythms and clock gene expression may influence the timing of parturition.
- Disruption of myometrial Bmal1 is associated with a delay in completing parturition.
- Serum progesterone levels did not differ between females with and without disrupted myometrial Bmal1 during late gestation.
- Uterine expression of contractile-associated proteins Connexin43 and Oxytocin receptor was similar in both groups during late gestation.
AI simplified