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Ghrelin, leptin, and glycemic control after sleeve gastrectomy versus Roux-en-Y gastric bypass—results of a randomized clinical trial
Changes in hunger and blood sugar hormones after sleeve gastrectomy versus gastric bypass surgery in a clinical trial
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Abstract
Percentage of excess weight loss at 12 months was 67.6±19.3% after sleeve gastrectomy and 64.2±18.5% after Roux-en-Y gastric bypass.
- Fasting ghrelin levels decreased significantly one month after sleeve gastrectomy and remained lower up to 12 months.
- In contrast, fasting ghrelin levels increased significantly after Roux-en-Y gastric bypass by 12 months.
- Leptin, glucose, insulin, C-peptide, glycated hemoglobin, and insulin resistance values all decreased significantly in both groups over the year.
- Both surgical procedures resulted in comparable improvements in glucose metabolism despite differing effects on ghrelin levels.
- The role of ghrelin in weight loss and metabolic changes post-surgery may be complex and influenced by various factors.
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