Obesity surgeryAug 17, 2018

Roux-en-Y Gastric Bypass improves blood sugar and fat levels after meals better than Sleeve Gastrectomy in non-diabetic severely obese patients: a short-term follow-up

GLP-1 Therapies Weekly Brief ↗PubMed ↗DOI ↗

Updated Mar 28, 2026

Abstract

Total cholesterol and LDL cholesterol levels were lower at 6 months after Roux-en-Y gastric bypass (RYGB) compared to sleeve gastrectomy (SG).

Both RYGB and SG resulted in comparable weight loss and improvement in fasting glucose, insulin, and insulin resistance.
Glucose levels after meals were significantly lower in the RYGB group compared to the SG group at both 3 and 6 months.
Triglyceride levels after meals were also significantly lower in the RYGB group compared to the SG group at 3 and 6 months.
There was no difference in postprandial insulin response between the two surgical procedures.
Findings suggest that RYGB may have specific effects on glucose and lipid metabolism due to its malabsorptive characteristics.

Simplified

PURPOSE: We aimed to compare the effects of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) on postprandial glucose and lipid metabolism in addition to weight loss and fasting metabolic profile, in non-diabetic patients undergoing bariatric surgery.

METHODS: Seventy-one patients were consecutively recruited and studied preoperatively, 3 and 6 months after surgery. Of these, 28 underwent RYGB (7 males, age 38 ± 9 years, BMI 46.9 ± 5.0 kg/m), and 43 SG (9 males, age 38 ± 9 years, BMI 50.2 ± 7.0 kg/m). A semi-liquid mixed meal was consumed, and blood samples were taken before, and every 30 min after meal ingestion up to 180 min postprandially, for measurement of glucose, insulin, and lipids. The overall postprandial response was assessed as area under the concentration-time curve (AUC). 2 2

RESULTS: Baseline metabolic parameters were similar between RYGB and SG. Both groups experienced comparable weight loss, and a similar improvement in fasting glucose, insulin, and insulin resistance. Total and LDL cholesterol levels were lower at 6 months after RYGB compared to SG, while there was no difference in HDL cholesterol or triglycerides. Glucose AUC was lower after RYGB compared to SG at both 3 (p = 0.008) and 6 months (p = 0.016), without any difference in postprandial insulin response. Triglyceride AUC was also lower in RYGB vs. SG at 3 and 6 months (p ≤ 0.001).

CONCLUSIONS: RYGB is superior to SG in improving postprandial glycaemia and lipaemia and cholesterol profile 6 months postoperatively in non-diabetic, severely obese patients. These findings imply procedure-specific effects, such as the malabsorptive nature of RYGB, and less likely a different incretin postoperative response.

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Roux-en-Y Gastric Bypass improves blood sugar and fat levels after meals better than Sleeve Gastrectomy in non-diabetic severely obese patients: a short-term follow-up

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