HSS journal : the musculoskeletal journal of Hospital for Special Surgery

GLP-1 Drugs and Their Effects on Bone Health and Surgery in Orthopedics

Updated

Abstract

Glucagon-like peptide-1 (GLP-1) receptor agonists may enhance bone mineral density and reduce bone resorption.

  • Basic science studies suggest GLP-1 agonists could positively affect bone health.
  • Clinical studies on fracture risk and bone health show mixed results.
  • The use of GLP-1 agonists in the perioperative setting may present challenges due to effects on gastric motility.
  • Proper glycemic control with GLP-1 agonists is associated with potential benefits for patients with diabetes or obesity undergoing orthopedic procedures.
  • Further research is required to clarify the long-term effects of GLP-1 agonists on bone health and their use in orthopedic patients.

Simplified

Full Text

Full text is available at the source.

Funding

Competing interests

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
PubMed

What Lands in Your Inbox Each Week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free