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GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans
GLP-1 may increase feelings of fullness before eating through appetite control areas in mice and humans
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Abstract
Administration of GLP-1 receptor agonists increased the sense of preingestive satiation in patients with obesity.
- GLP-1 receptor neurons in the dorsomedial hypothalamus may encode preingestive satiation.
- Manipulating DMH neurons resulted in induced satiation.
- Calcium imaging indicated that DMH neurons are actively involved in the encoding of preingestive satiation.
- GLP-1 receptor agonists selectively heightened DMH neuron activity during eating.
- An interaction between DMH neurons and neuropeptide Y/agouti-related peptide neurons in the arcuate nucleus may regulate food intake.
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