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Molecular connectomics reveals a glucagon-like peptide 1-sensitive neural circuit for satiety
A brain circuit sensitive to glucagon-like peptide 1 linked to feeling full
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Abstract
At least 21 afferent subtypes of hunger-promoting AgRP neurons were identified in the mouse hypothalamus.
- Liraglutide and other GLP-1 receptor agonists may suppress appetite by activating specific neurons.
- Among identified subtypes, TRH neurons are activated by liraglutide and inhibit AgRP neurons.
- Activation of TRH neurons is associated with reduced feeding behavior.
- Silencing TRH neurons could lead to overeating and weight gain.
- Liraglutide's effectiveness on body weight may be diminished when TRH neurons are silenced.
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