The hidden impact of GLP‐1 receptor agonists on endometrial receptivity and implantation

Dec 19, 2024Acta obstetricia et gynecologica Scandinavica

How GLP-1 receptor drugs may affect the uterus’s readiness for embryo implantation

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Abstract

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) may improve female fertility by stimulating ovulation.

Infertility rates are increasing due to sociocultural trends, lifestyle factors, and health problems.
Obesity disrupts ovulation, contributing to rising infertility, particularly among women.
While GLP-1RAs are used for obesity and type 2 diabetes, their impact on female fertility is not fully understood.
The effects of GLP-1RAs on the endometrium, which is crucial for embryo implantation, require further investigation.
Research is needed to explore the safety and developmental outcomes for children born to women conceiving during GLP-1RA treatment.

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Increasing infertility rates represent a growing medical challenge in modern societies resulting from a complex interplay of sociocultural trends, lifestyle factors, exposure to environmental toxins, and underlying health problems. Women's fertility is particularly vulnerable to these shifts. The obesogenic lifestyle not only accelerates weight gain, but also disrupts ovulation driving the rise in infertility. Among several medications used for treating obesity and type 2 diabetes, glucagon-like peptide-1 receptor agonists (GLP-1RAs) show promising improvement in female fertility most likely by stimulating ovulation. However, the effects of GLP-1RAs on the endometrium remain unclear. Further studies are needed to investigate the impact of GLP-1RAs on and embryo implantation and early development. The aim of this study is to address the knowledge gap regarding the effects of GLP-1RAs on human reproduction, with special focus on the endometrium. Understanding these mechanisms may help to develop new strategies for improving fertility treatment, reduce implantation failure and address potential safety concerns regarding teratogenicity and adverse developmental outcomes for children born to women conceiving during or soon after GLP-1RA treatment.

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The hidden impact of GLP‐1 receptor agonists on endometrial receptivity and implantation

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