Diabetes, obesity & metabolism

Safety Warnings for GLP-1 Receptor Agonists from Multiple Drug Safety Databases (2018–2025) with Bias Checks and Prioritized Risk Levels

Updated

Abstract

The safety profile of GLP-1 receptor agonists is incompletely characterized.

  • GLP-1 receptor agonists are commonly used to treat type 2 diabetes and obesity.
  • Potential safety concerns include psychiatric, vascular, neoplastic, and rare eye-related events.
  • The current understanding of these safety issues may be affected by various biases, such as confounding by indication and notoriety bias.

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