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How GLP-1 Receptor Agonists May Help Pulmonary Hypertension: Mechanisms, Animal Studies, and Unknowns in Human Treatment

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Abstract

Pulmonary hypertension frequently coexists with type 2 diabetes, obesity, and heart failure with preserved ejection fraction.

  • Glucagon-like peptide-1 (GLP-1) receptor agonists and dual GIP/GLP-1 receptor agonists have been shown to improve several cardiometabolic conditions.
  • These agents may have anti-inflammatory and vascular effects.
  • It is currently unknown if GLP-1 receptor agonists directly affect pulmonary blood flow or clinical outcomes in pulmonary hypertension.

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