Trend 2010–2018 in the clinical use of GLP-1 receptor agonists for the treatment of type 2 diabetes in routine clinical practice: an observational study from Northeast Italy

Nov 2, 2019Acta diabetologica

Changes from 2010 to 2018 in the use of GLP-1 medicines for type 2 diabetes treatment in everyday care in Northeast Italy

AI simplified

GLP-1 Therapies on OpenScience ↗PubMed ↗DOI ↗

Abstract

Among 6167 cases of GLP-1 receptor agonist (GLP-1RA) initiation, 5408 were analyzed from a population of approximately 1.38 million inhabitants.

The prescription of GLP-1RAs increased significantly from 2010 to 2018.
Patients initiating GLP-1RA showed higher baseline age, longer diabetes duration, and increased prevalence of cardiovascular disease over the years.
There was a notable rise in the number of insulin users among those starting GLP-1RAs.
Blood pressure and cholesterol levels decreased alongside the rising use of cardiovascular risk medications.
Average baseline HbA1c (8.3% [67 mmol/mol]) and BMI (34 kg/m²) remained consistent throughout the study period.

AI simplified

AIMS: Several GLP-1 receptor agonists (GLP-1RA) have become available for the treatment of type 2 diabetes (T2D), and evidence on their beneficial effects has evolved. We evaluated how the clinical phenotype of patients initiating GLP-1RA changed from 2010 to 2018.

METHODS: This was a retrospective study conducted at six diabetes outpatient clinics in Northeast Italy. We collected data of T2D patients who initiated new GLP-1RA between 2010 and 2018. We recorded baseline characteristics, including demographics, anthropometrics, cardiovascular risk factors, glucose control, lipid profile, liver enzymes, renal function and concomitant medications. We recorded updated HbA1c and body weight at follow-up.

RESULTS: There were 83,116 T2D patients from a general population of ~ 1,380,000 inhabitants. Among 6167 cases of GLP-1RA initiation, 5408 were analyzed after excluding intra-class switchers. Prescription of GLP-1RA increased exponentially, and the change in the type of GLP-1RA reflected waves of their entering the market. From 2010 to 2018, there were significant increases in baseline age, diabetes duration and prevalence of male sex, of cardiovascular disease and of insulin users. Blood pressure and cholesterol levels decreased concomitantly with increasing use of medications for the control of cardiovascular risk. Baseline average HbA1c (8.3% [67 mmol/mol]) and BMI (34 kg/m) and their improvement after GLP-1RA initiation did not change over time. 2

CONCLUSIONS: Despite the early positioning of GLP-1RA in T2D treatment algorithms, GLP-1RA have been prescribed in patients with progressively more advanced disease stage and especially in the presence of cardiovascular disease. Optimization of GLP-1RA use in routine clinical practice is still needed.

Full Text

Full text is available at the source.

View full text (PDF) ↗View full text (HTML) ↗

Trend 2010–2018 in the clinical use of GLP-1 receptor agonists for the treatment of type 2 diabetes in routine clinical practice: an observational study from Northeast Italy

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the glp-1 therapies brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the glp-1 therapies brief