We can’t show the full text here under this license.
Use of Glucagon-like Peptide-1 Receptor Agonists Around Surgery Linked to Lower Rates of Failed Bone Healing After Long Spine Deformity Correction
Updated
Abstract
Essence
Perioperative GLP-1 receptor agonist use was associated with lower after long-segment spinal deformity surgery.
Evidence
A 1:1 propensity-matched retrospective cohort of adults undergoing posterior spinal deformity instrumentation across seven or more levels compared GLP-1 RA use within six months before or after surgery with no use.
Caveat
Because treatment assignment was observational and exposure could occur before or after surgery, residual confounding and timing ambiguity limit causal interpretation.
Simplified
Key numbers
0.677
Decrease in Risk at 6 Months
Risk ratio for at 6 months in GLP-1 RA users vs. non-users.
0.485
Decrease in Sepsis Risk
Risk ratio for sepsis within 90 days in GLP-1 RA users vs. non-users.
GLP-1 Therapies