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Abstract
Fasting states and glucagon stimulation induce Foxa2 acetylation at Lys259, influencing metabolic regulation.
- Foxa2 plays a key role in lipid metabolism and ketogenesis during fasting.
- Inhibition of histone deacetylases leads to acetylation of Foxa2 at a specific residue.
- Cofactors p300 and SirT1 are involved in the processes of Foxa2 acetylation and deacetylation.
- Mutations that mimic or prevent acetylation at Lys259 affect Foxa2 activity in opposite ways.
- Adenoviral expression of the acetylation-mimicking form of Foxa2 increases the expression of genes related to fatty acid oxidation and ketogenesis.
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