Glucagon-Induced Acetylation of Foxa2 Regulates Hepatic Lipid Metabolism

Fasting states and glucagon stimulation induce Foxa2 acetylation at Lys259, influencing metabolic regulation.

• Foxa2 plays a key role in lipid metabolism and ketogenesis during fasting.
• Inhibition of histone deacetylases leads to acetylation of Foxa2 at a specific residue.
• Cofactors p300 and SirT1 are involved in the processes of Foxa2 acetylation and deacetylation.
• Mutations that mimic or prevent acetylation at Lys259 affect Foxa2 activity in opposite ways.
• Adenoviral expression of the acetylation-mimicking form of Foxa2 increases the expression of genes related to fatty acid oxidation and ketogenesis.

AI simplified