Lysine Acetylation of CREBH Regulates Fasting-Induced Hepatic Lipid Metabolism

Fasting induces acetylation of CREBH in mouse livers, which is crucial for its role in regulating lipid metabolism.

• CREBH is a transcription factor that plays a key role in maintaining energy balance in the liver.
• Acetylation of CREBH occurs in a time-dependent manner during fasting, affecting its transcriptional activity.
• The balance between acetylation by the enzyme PCAF and deacetylation by sirtuin-1 regulates the acetylation state of CREBH.
• The specific lysine residue at position 294 (K294) is essential for fasting-induced acetylation and subsequent gene activation.
• Mutations at K294 impact CREBH's ability to regulate target genes and can lead to conditions like hepatic steatosis and hyperlipidemia during prolonged fasting.

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