Liver-Enriched Transcription Factor CREBH Interacts With Peroxisome Proliferator-Activated Receptor α to Regulate Metabolic Hormone FGF21

CREBH and PPARα form a functional complex that regulates FGF21 gene expression and lipid metabolism.

• CREBH is involved in regulating triglyceride and fatty acid metabolism under fasting and atherogenic high-fat diet conditions.
• The interaction between CREBH and PPARα is necessary for the expression of the metabolic hormone FGF21.
• Both CREBH and PPARα work together to activate FGF21 gene expression, with PPARα depending on CREBH for its activation effects.
• Infusion of recombinant FGF21 can reverse hypertriglyceridemia and hypoketonemia in CREBH-null mice fed an atherogenic high-fat diet.
• The study suggests a regulatory axis of CREBH-PPARα-FGF21 is important for maintaining lipid balance during metabolic stress.

AI simplified