CREBH helps keep daily blood sugar balance by controlling liver sugar breakdown and production

CREBH is identified as a key metabolic regulator that controls glucose homeostasis across the circadian cycle.

• CREBH is a liver-specific transcription factor that regulates the body's response to stress and lipid levels.
• Its activity is influenced by the circadian clock, affecting processes related to glucose storage and release.
• The rhythmic expression of key enzymes involved in glucose production and storage is controlled by CREBH.
• CREBH interacts with another protein, PPARα, enhancing its ability to regulate glucose metabolism.
• Deficiency in CREBH results in lower blood glucose levels and higher glycogen levels in the liver, particularly during the day or fasting.

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