How Drugs That Activate the Glucagon-Like Peptide-1 Receptor Affect Body Fat and Muscle

The mean percentage of fat-free mass lost with GLP-1 receptor agonist treatments is 29.1%.

• The average fat-free mass loss is based on a review of 40 reports using DXA imaging.
• Weight loss from diet-induced changes typically results in about 25% fat-free mass loss, though this varies significantly.
• Changes in body composition with GLP-1 receptor agonists are higher than those seen with other nonsurgical obesity interventions.
• Further evaluation of strength and performance measures, along with the effects of new GLP-1 agents, is necessary to address existing knowledge gaps.

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