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Genetically proxied glucagon-like peptide-1 receptor agonist is associated with risk of tubulo-interstitial nephritis: A network Mendelian randomization study
Genetic evidence linking glucagon-like peptide-1 receptor activators to risk of kidney tubule inflammation
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Abstract
GLP1R agonist use is associated with a 2.32-fold increased risk of chronic .
- analysis indicates a significant causal relationship between GLP1RA use and chronic tubulo-interstitial nephritis (CTIN).
- No significant association was observed for acute tubulo-interstitial nephritis (ATIN).
- Colocalization analysis supports the genetic link between GLP1R expression and CTIN, with a high probability of shared genetic variants.
- Four plasma proteins (HYAL1, NMNAT1, IL12RB2, and DPP6) were identified as partial mediators of the effect.
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Key numbers
2.32
Increase in Risk of
Odds ratio from analysis.
4
Identified Mediators
Four partially mediate the effect of GLP1RAs on .