Effects and Considerations of Glucagon-like Peptide-1 Receptor Agonists in Joint Replacement Surgery

GLP-1 receptor agonists are increasingly used for weight loss management in obese patients.

• GLP-1 receptor agonists are primarily known for their role in glycemic control among diabetic patients.
• There is emerging interest in the perioperative implications of GLP-1 receptor agonists for total joint arthroplasty (TJA) patients.
• The review addresses complications and adverse effects associated with GLP-1 receptor agonist use.
• Considerations for anesthesiologists and TJA surgeons regarding GLP-1 receptor agonists are discussed.
• Clinical practice recommendations for GLP-1 receptor agonist use in 2025 are highlighted.

Simplified