How Blood Sugar Levels During a Glucose Test Relate to Pregnancy Problems in Women Without Diabetes

The incidence of adverse pregnancy outcomes increased progressively from the small AUC pattern to the medium and large AUC patterns in a cohort of 23,577 pregnant women.

• Different glucose patterns identified based on the area under the curve (AUC) of the oral glucose tolerance test (OGTT) were small AUC (SA), medium AUC (MA), and large AUC (LA).
• A positive dose-response relationship was observed between the AUC-OGTT and the risk of adverse pregnancy outcomes, such as preeclampsia and macrosomia.
• The medium AUC pattern was associated with higher risks of macrosomia and cesarean delivery, with relative risks of 1.34 and 1.09, respectively.
• The large AUC pattern was linked to increased risks for preeclampsia, preterm birth, macrosomia, and cesarean delivery, with relative risks of 1.20, 1.68, and 1.15, respectively.
• The risks associated with OGTT patterns varied according to maternal age and preconception body mass index (BMI).

Simplified