Glucose restriction induces AMPK-SIRT1-mediated circadian clock gene Per expression and delays NSCLC progression

Glucose restriction may enhance apoptosis and delay growth in non-small cell lung cancer (NSCLC) cells.

• Disturbed circadian clock rhythms may be linked to metabolic diseases and cancers.
• Higher expression of the circadian clock gene Per is associated with better prognosis in cancer patients.
• Glucose restriction was found to induce Per expression in NSCLC cells through the activation of AMPK.
• A low-carbohydrate ketogenic diet significantly delayed tumor progression in a mouse model.
• The ketogenic diet increased the expression of AMPK, SIRT1, and Per in vivo.
• The ketogenic diet restored the normal rhythmic level of Per in experimental conditions.

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