Ketogenic diet delays body clock timing without changing energy sensor activity in mouse liver

KD led to a 1.5-fold increase in blood glucose and insulin levels.

• AMPK activation is associated with increased hepatic glucose output despite expectations to inhibit gluconeogenesis.
• Brain levels of pAMPK were 40% higher in KD-fed mice, while liver levels remained unchanged.
• Down-regulation of the pP70S6K/P70S6K ratio occurred by 40% in the brain and 20% in the liver under KD.
• SIRT1 levels were found to be 40% higher in the brain but 40% lower in the liver of KD-fed mice.
• Clock gene expression showed altered rhythms, with delayed rhythms in KD-fed mice and increased amplitude in the liver.

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