Gonadotropin‐Releasing Hormone Exhibits Circadian Rhythm in Phase with Arginine‐Vasopressin in Co‐Cultures of the Female Rat Preoptic Area and Suprachiasmatic Nucleus

Jun 9, 2000Journal of neuroendocrinology

Daily rhythms of reproductive hormone align with a brain clock signal in female rat brain tissue

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Abstract

The release of gonadotropin-releasing hormone (GnRH) in cocultures exhibited a significant circadian rhythm in the presence of oestrogen.

  • GnRH release followed a circadian pattern when oestrogen was present, but not in its absence.
  • The circadian rhythm of GnRH matched that of arginine-vasopressin, while differing from that of vasoactive intestinal polypeptide (VIP).
  • The peak of the GnRH rhythm coincided with the peak of the arginine-vasopressin rhythm in cocultures.
  • Administration of arginine-vasopressin increased GnRH release in single preoptic area cultures with oestrogen, while VIP did not.
  • Arginine-vasopressin neurons in the suprachiasmatic nucleus may regulate the circadian release of GnRH in the presence of oestrogen.

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