Journal of neuroendocrinology

Daily rhythms of reproductive hormone align with a brain clock signal in female rat brain tissue

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

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Abstract

The release of gonadotropin-releasing hormone (GnRH) in cocultures exhibited a significant circadian rhythm in the presence of oestrogen.

  • GnRH release followed a circadian pattern when oestrogen was present, but not in its absence.
  • The circadian rhythm of GnRH matched that of arginine-vasopressin, while differing from that of vasoactive intestinal polypeptide (VIP).
  • The peak of the GnRH rhythm coincided with the peak of the arginine-vasopressin rhythm in cocultures.
  • Administration of arginine-vasopressin increased GnRH release in single preoptic area cultures with oestrogen, while VIP did not.
  • Arginine-vasopressin neurons in the suprachiasmatic nucleus may regulate the circadian release of GnRH in the presence of oestrogen.

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