A Gq-Ca2+ Axis Controls Circuit-Level Encoding of Circadian Time in the Suprachiasmatic Nucleus

Apr 30, 2013Neuron

A calcium-based signaling pathway controls how the brain’s circadian clock processes time

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Abstract

Activation of Gq-dependent pathways in a minority of neurons reprogrammed intracellular calcium levels and circadian rhythms across the entire suprachiasmatic nucleus (SCN).

  • Circadian oscillations of intracellular calcium levels were visualized alongside the activation of calcium/cAMP-responsive elements.
  • G-coupled vasoactive intestinal peptide (VIP) signaling was found to be essential for the dependence of these calcium oscillations on the transcriptional/post-translational feedback loops.
  • Pharmacogenetic manipulation indicated that Gq, Gs, and Gi pathways each contributed differently to the regulation of cytosolic and circadian rhythms.
  • The study identified a specific Gq/[Ca2+]i-VIP mechanism that suggests increased plasticity in how the SCN encodes circadian time.

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