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Preventive effect of grape seed extract against high-fructose diet-induced insulin resistance and oxidative stress in rats
Grape seed extract may prevent insulin resistance and oxidative stress caused by a high-fructose diet in rats
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Abstract
After 8 weeks, fasting plasma glucose and insulin levels were significantly lower in rats fed a high-fructose diet supplemented with 1% grape seed extract.
- Insulin resistance, measured by HOMA-IR, was significantly reduced in rats given grape seed extract compared to those on a high-fructose diet alone.
- Grape seed extract improved glucose intolerance, as indicated by lower plasma glucose and insulin concentrations after a glucose challenge.
- Supplementation with grape seed extract increased the activity of antioxidant enzymes, including superoxide dismutase and catalase, in the liver.
- Lipid peroxidation was suppressed in rats supplemented with grape seed extract compared to those without it.
- No significant change in the activity of hepatic glutathione peroxidase was observed with grape seed extract supplementation.
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