Keeping time in group 3 innate lymphoid cells

Aug 8, 2020Nature reviews. Immunology

How group 3 innate lymphoid cells keep track of time

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Abstract

Group 3 innate lymphoid cells (ILC3s) in the intestinal mucosa are influenced by circadian rhythms.

  • The gastrointestinal tract processes microbial and nutrient signals daily, which may affect ILC3 function.
  • Circadian rhythms appear to regulate the biological activities of ILC3s.
  • Environmental cues and clock genes are involved in modulating ILC3 behavior.
  • Recent reports contribute to understanding the relationship between circadian clocks and intestinal immunity.

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