How group 3 innate lymphoid cells keep track of time

Group 3 innate lymphoid cells (ILC3s) in the intestinal mucosa are influenced by circadian rhythms.

• The gastrointestinal tract processes microbial and nutrient signals daily, which may affect ILC3 function.
• Circadian rhythms appear to regulate the biological activities of ILC3s.
• Environmental cues and clock genes are involved in modulating ILC3 behavior.
• Recent reports contribute to understanding the relationship between circadian clocks and intestinal immunity.

Simplified